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Drug: Dexamethasone

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Total 6567 results found since Jan 2013.

BET 2: Dexamethasone for reduction of migraine recurrence
Report by: Andrew Neill, Registrar Emergency Medicine Search checked by: Domhnall Brannigan, Consultant Emergency Medicine Institution: St Vincent's University Hospital, Dublin, Ireland Abstract A short-cut review was carried out to establish whether the administration of dexamethasone reduced the risk of recurrence of migraine headaches at 24 h. Three hundred and fifteen articles were found using the reported search including two systematic reviews and meta-analyses. A total of nine trials was included between the two meta-analyses. One trial was included in both analyses from the abstract data but had subsequently b...
Source: Emergency Medicine Journal - January 24, 2013 Category: Emergency Medicine Tags: EMJ Best evidence topic reports, Headache (including migraine), Pain (neurology), Pregnancy Source Type: research

Role of Dexamethasone in the Prevention of Migraine Recurrence in the Acute Care Setting:
A Review Christopher Giuliano, PharmD; Roger D. Smalligan, MD, MPH; Greg Mitchon, ; Matt Chua, MD DOI: 10.3810/pgm.2012.05.2554 Abstract: Patients with migraine headaches are commonly encountered by clinicians both in the clinic and in the emergency department. Migraines impose a significant financial burden on patients, caregivers, and society. Up to 49% of patients treated acutely for migraine headache will have a recurrence within 72 hours. Recurrence of migraines is dependent on a number of factors, including the choice of abortive agent, age, sex, and initial severity of the migraine. Dexamethasone has been...
Source: Postgraduate Medicine Online - June 4, 2012 Category: Internal Medicine Authors: admin Source Type: research

Evaluation of Occipital Nerve Blocks for Acute Pain Relief of Migraines.
Abstract Migraines are a debilitating neurological disease affecting as many as 1 of 6 adults in the United States. Occipital nerve block, consisting of a local anesthetic and/or corticosteroid, has shown to be an effective treatment for the management of migraines. Occipital nerve block has been reported to reduce migraine pain scores, frequency, and duration. We aimed to evaluate the impact of occipital nerve block for acute pain relief in patients with migraines. This was a single-center retrospective observational study conducted at a 1162-bed academic medical center in Gainesville, Florida. Included patients ...
Source: The Journal of Clinical Pharmacology - October 7, 2019 Category: Drugs & Pharmacology Authors: Ebied AM, Nguyen DT, Dang T Tags: J Clin Pharmacol Source Type: research

8 Health Risks of Untreated Depression
Medication side-effects can seem unbearable at times: dry mouth, nausea, dizziness, constipation. Certain prescriptions can also increase our risks for developing chronic conditions like thyroid disease and diabetes. Three years ago, I decided that the pills’ side-effects weren’t worth the relief they brought, so I slowly weaned off all my medication. I then plummeted into a severe depression that ended up taking a far greater toll on my health than the nuisance of my drugs. You may be justifiably concerned about how your mood stabilizer and antidepressant are altering your biochemistry, but also consider the grave con...
Source: World of Psychology - March 5, 2019 Category: Psychiatry & Psychology Authors: Therese J. Borchard Tags: Depression General Medications Antidepressant Cognitive Decline Diabetes Mood Stabilizer Source Type: blogs

Steroids for preventing recurrence of acute severe migraine headaches: a meta‐analysis
ConclusionWhen steroids are added to standard abortive therapy for migraine headaches, they are effective and safe for preventing moderate or severe headache recurrence.
Source: European Journal of Neurology - April 13, 2013 Category: Neurology Authors: Y. Huang, X. Cai, X. Song, H. Tang, Y. Huang, S. Xie, Y. Hu Tags: Original Article Source Type: research

The Acute Treatment of Migraine in Adults: The American Headache Society Evidence Assessment of Migraine Pharmacotherapies
The study aims to provide an updated assessment of the evidence for individual pharmacological therapies for acute migraine treatment. Pharmacological therapy is frequently required for acutely treating migraine attacks. The American Academy of Neurology Guidelines published in 2000 summarized the available evidence relating to the efficacy of acute migraine medications. This review, conducted by the members of the Guidelines Section of the American Headache Society, is an updated assessment of evidence for the migraine acute medications. A standardized literature search was performed to identify articles related to acute ...
Source: Headache: The Journal of Head and Face Pain - January 20, 2015 Category: Neurology Authors: Michael J. Marmura, Stephen D. Silberstein, Todd J. Schwedt Tags: American Headache Society Evidence Assessment Source Type: research

The acute treatment of migraine in adults: the american headache society evidence assessment of migraine pharmacotherapies.
Abstract The study aims to provide an updated assessment of the evidence for individual pharmacological therapies for acute migraine treatment. Pharmacological therapy is frequently required for acutely treating migraine attacks. The American Academy of Neurology Guidelines published in 2000 summarized the available evidence relating to the efficacy of acute migraine medications. This review, conducted by the members of the Guidelines Section of the American Headache Society, is an updated assessment of evidence for the migraine acute medications. A standardized literature search was performed to identify articles...
Source: Headache - January 1, 2015 Category: Neurology Authors: Marmura MJ, Silberstein SD, Schwedt TJ Tags: Headache Source Type: research

Management of Adults With Acute Migraine in the Emergency Department: The American Headache Society Evidence Assessment of Parenteral Pharmacotherapies
ConclusionsThe search identified 68 unique randomized controlled trials utilizing 28 injectable medications. Of these, 19 were rated class 1 (low risk of bias), 21 were rated class 2 (higher risk of bias), and 28 were rated class 3 (highest risk of bias). Metoclopramide, prochlorperazine, and sumatriptan each had multiple class 1 studies supporting acute efficacy, as did dexamethasone for prevention of headache recurrence. All other medications had lower levels of evidence. RecommendationsIntravenous metoclopramide and prochlorperazine, and subcutaneous sumatriptan should be offered to eligible adults who present to an ED ...
Source: Headache: The Journal of Head and Face Pain - June 13, 2016 Category: Neurology Authors: Serena L. Orr, Benjamin W. Friedman, Suzanne Christie, Mia T. Minen, Cynthia Bamford, Nancy E. Kelley, Deborah Tepper Tags: Review Article Source Type: research

The Place of Corticosteroids in Migraine Attack Management: a 65-year Systematic Review with Pooled Analysis and Critical Appraisal (S23.007)
CONCLUSIONS: Our literature review suggests that with corticosteroid treatment, recurrent headaches become milder than pretreated headaches and later respond to nonsteroidal therapy. Single-dose intravenous dexamethasone is a reasonable option for managing resistant, severe, or prolonged migraine attacks.Disclosure: Dr. Woldeamanuel has nothing to disclose. Dr. Rapoport has received personal compensation for activities with Pfizer Inc, Endo Pharmaceuticals, Nupathe, and MAP Pharmaceuticals. Dr. Cowan has received personal compensation for activities with Allergan, Inc., MAP Pharmaceuticals, Nautilus Neurosciences, and Nupathe.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Woldeamanuel, Y., Rapoport, A., Cowan, R. Tags: Headache: Epidemiology and Clinical Source Type: research

Efficacy of ketorolac in the treatment of acute migraine attack: a systematic review and meta-analysis
CONCLUSIONS: Ketorolac may have similar efficacy to phenothiazines and metoclopramide in treating acute migraine headache. Ketorolac may also offer better pain control than sumatriptan, dexamethasone and sodium valproate. However, given the lack of evidence due to inadequate number of trials available, future studies are warranted.PMID:35138658 | DOI:10.1111/acem.14457
Source: Accident and Emergency Nursing - February 9, 2022 Category: Emergency Medicine Authors: Nurathirah Mohd Noor Mohd Boniami Yazid Norhayati Mohd Noor Kamarul Aryffin Baharuddin Mimi Azliha Abu Bakar Source Type: research

Age But Not Sex Is Associated With Efficacy and Adverse Events Following Administration of Intravenous Migraine Medication: An Analysis of a Clinical Trial Database.
CONCLUSION: Sex was not associated with response to parenteral acute migraine medication. Age was associated with both efficacy and adverse events. PMID: 26486928 [PubMed - as supplied by publisher]
Source: Headache - October 21, 2015 Category: Neurology Authors: Friedman BW, Cisewski DH, Holden L, Bijur PE, Gallagher EJ Tags: Headache Source Type: research